Coexisting Cardiac and Hematologic Disorders

Parvovirus-B19 and hematologic disorders.

Parvovirus-B19 (PV-B19) is a member of Parvoviridae, which is one of the smallest DNA viruses. PV-B19-associated diseases usually serve as a good representation of the balance of virus, host response and the immune system. The diseases manifested with PV-B19 are erythema infectiosum, which is common in children, hydrops fetalis, transient pure red cell aplasia in patients with chronic hemolytic...

Abnormal ("ringed") sideroblasts in various hematologic and non-hematologic disorders.

Chapter 7: Hematologic Disorders and Kidney Disease

Pathogenesis Multiple myeloma (MM) is a hematologic malignancy involving the pathologic proliferation of terminally differentiated plasma cells. It is the second most common hematologic malignancy behind non-Hodgkin lymphoma, with an annual incidence of 4–7 cases per 100,000 in the United States. Clinical symptoms are due to osteolysis of the bone, suppression of normal hematopoiesis, and the o...

Coexisting Disorders in Children with Epilepsy*

Children with epilepsy often manifest comorbid conditions, some causally related to the seizure activity (eg, congenital malformation, injury, metabolic disturbance, tumors) and others due to the epilepsy treatment (eg, behavioral complications due to antiepileptic drugs [AEDs]). Repeated seizure activity is associated with cognitive regression, behavioral disturbance, social disability, and sl...

Vascular complications after splenectomy for hematologic disorders.

The most widely recognized long-term risk of splenectomy is overwhelming bacterial infection. More recently, thrombosis has become appreciated as another potential complication of the procedure. Because of these long-term risks, the indications for and timing of splenectomy are debated in the medical community. Accordingly, the adverse effects and benefits of splenectomy for hematologic disorde...